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Jossy Onwude, MD Reviewed by Kenya Bass, PA-C Published Jul 8, 2025 13 min read Melatonin has become one of the most popular supplements for sleep, and for good reason

Though early work from companies like Vertex (Semma Tx acquisition) are focused on regeneration of pancreatic islets (for diabetes), Novo Nordisk recently inked a deal (including $75M upfront) with early-stage cell therapy player Aspect Biosystems

The American College of Gastroenterology guidelines for IBS management emphasize the importance of comprehensive medication counseling and established follow-up plans for patients with functional gastrointestinal disorders

A diagnosis of obesity or overweight, along with any related health conditions (comorbidities) such as high blood pressure, diabetes, or sleep apnea

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Regular follow-ups with healthcare providers will ensure the medication is effective in supporting weight loss goals and can be tailored to meet specific needs, helping individuals stay on track for long-term success