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In a similar model, intrathecal injections of exenatide inhibited thermal hyperalgesia and mechanical allodynia by enhancing spinal microglial expression of -endorphins, IL-10 and interleukin 4 (IL-4) [34, 35]

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The prevalence and incidence of IBD are rising worldwide, placing a significant burden on healthcare systems and social resources ( A promising explanation could be represented by the complex interplay between inflammation and metabolism, which is still largely unknown in the field of IBD management

Although no supplement can substitute for adequate nutrition and regular exercise