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Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Body Weight Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA, 325 (14): 14141425

Notably, the atypical antipsychotics with the largest weight gain profiles, olanzapine and clozapine, also display high affinities for the H1R (170173)

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Advanced approaches, such as CRISPR-based gene editing of bacterial metabolic pathways, could also be employed to optimize dihydroferulic acid production and assess its direct impact on GLP-1 secretion

Additionally, most GLP-1s currently on the market are delivered via injection, but research and development is underway on pill-based forms

however, it requires self-administration via syringe , increasing complexity and risk of dosing errors