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How we eat matters too

(MP4 3429 kb) Studies investigating the mechanism of action of GLP-1RA therapy for causing weight loss provide evidence that GLP-1RA treatment is associated with reductions in appetite and hunger, lower preference for energy-dense foods, alteration in food reward pathways, decrease in food cravings, and improvement in eating control (Table 2) [25, 26, 33, 34]

These findings argue against a hepatic portal site of action of GLP-1 to inhibit eating, and further emphasize that the route of administration is an important consideration when analyzing food intake inhibition by GLP-1R agonism

*Correspondence: Arjola Bano, [email protected] These authors have contributed equally to this work This article was submitted to Cardiovascular and Smooth Muscle Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Weight Management: Many women with PCOS struggle with weight gain and obesity, which can further exacerbate their condition

Am J Clin Nutr 118(3):614626 Peterson SC, Barry AR (2018) Effect of glucagon-like peptide-1 receptor agonists on all-cause mortality and cardiovascular outcomes: a meta-analysis