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The half-lives of compounds 1 , 2 , 5 , 9 , 11 , 14 , 16 , 22 and 23 in presence of NEP 24.11 and in presence of mouse plasma were determined by following the decay of the analogues by LCMS (Table 2)
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GLP-1 is secreted in response to food intake and has several effects: it stimulates insulin secretion from the pancreas in a glucose-dependent manner, suppresses glucagon release (a hormone that increases blood glucose levels), slows gastric emptying, and reduces appetite
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