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In islet alpha cells, GLP-1(936) led to inhibition of Ca2+ entry via voltage-gated Ca2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049

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Do not administer weekly GLP-1 receptor agonists every 5 daysthis shortened dosing interval is not supported by any clinical evidence and may increase adver...

Szacuje si, e w populacji polskiej z nadwag zmaga si a 44% wszystkich mczyzn i 30% kobiet, a liczba ta stale ronie i obejmuje coraz to modsze roczniki