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Patients with pancreatic history should proceed cautiously

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The Initial Phase: Weeks 1-4 During the first several weeks on the lowest dose, most people notice a subtle reduction in appetite, feeling fuller sooner during meals, and less interest in snacking

Tirzepatide (Mounjaro, Zepbound) targets two pathways and tends to produce greater weight loss in head-to-head studiesroughly 20% body weight loss on tirzepatide vs 15% on semaglutide

Dose adjustments cannot compensate for untreated hormonal instability or ongoing muscle loss

Comparison of treatment with sitagliptin or sulfonylurea in patients with type 2 diabetes mellitus and mild renal impairment: a post hoc analysis of clinical trials