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Additionally, the impact of the loss of GLP-2R signaling on the intestinal response to increased food intake with cold stress was maintained in the duodenum and jejunum of male mice aged to 25 weeks, demonstrating conservation of this response with age (Supplementary Fig
The clinical expert consulted by CADTH on this review did note that, in their experience, if patients are seeing a benefit from drug therapy, they are more likely to put up with the GI side effects and that GI side effects do tend to improve with time or can be managed with a more gradual dose escalation than that stated in the product monograph
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Association between pioglitazone use and prostate cancer: a population-based case-control study in the Han population
