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Efpeglenatide (a modified exendin conjugated to human immunoglobulin-4 via a polyethylene glycol linker) has shown metabolic efficacy and cardiorenal benefits as a once-weekly subcutaneous injection during Phase 3 trials, but has yet to be progressed further [38]

The pituitary gland itself remains active and engaged, potentially preventing the atrophy that occurs with exogenous hormone replacement

Once-weekly GLP-1s (Semaglutide & Tirzepatide) have done what marketing couldnt theyve turned a medical treatment into a global movement

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Agrawal, M., Hegselmann, S., Lang, H., Kim, Y

Furthermore, it suppresses oxidative stress by scavenging free radicals and enhancing the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase (Morya et al., 2025)