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Methods Study design and participants SURMOUNT-1 was a phase 3 randomised, double-blind, placebo-controlled trial in which adults with a body mass index (BMI) 30 kg/m 2 or 27 kg/m 2 and at least one weight-related complication, excluding diabetes, were assigned to once weekly, subcutaneous tirzepatide (5 mg, 10 mg or 15 mg) or placebo for 72 weeks as an adjunct to lifestyle intervention

Subcutaneous injection delivers approximately 80 percent of the dose to the bloodstream

Benefits of Semaglutide and Tirzepatide for Weight Loss Both semaglutide and tirzepatide offer multiple benefits beyond dropping pounds

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Note the date and approximate duration each time the vial spends time outside the fridge beyond routine injections

Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin: This can be both a serious and common side effect