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Lizcano and colleagues investigated a novel class of molecules called GLP-1 and estrogen conjugates, engineered compounds that chemically link GLP-1 and estrogen into a single therapeutic agent [2]
The most common secondary damage is ipsilateral thalamic degeneration after cerebral infarction, including axonal degeneration, neuronal loss, gliosis, -amyloid (A) deposits, and hyperphosphorylation of Tau protein (152, 153)

Patients with pre-existing gastroparesis, significant gastrointestinal disease, or previous gastric surgery require particularly careful monitoring and may benefit from gastroenterology consultation before initiating GLP-1 agonist therapy

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