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The TRIUMPH-1 trial enrolled adults with a BMI of 30 or above, or a BMI of at least 27 plus a weight-related health condition

18 They found that patients taking semaglutide were more likely to develop NAION at two, three and four years after initiation of treatment, with a cumulative HR of 2.22 after four years compared to control (n=45 vs 29)

Their primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood sugar levels with a low risk of hypoglycaemia when used alone (though risk increases when combined with insulin or sulfonylureas) Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which prolongs the feeling of fullness after meals Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger and food intake These combined effects result in improved glycaemic control for people with diabetes and significant weight loss

Since FBF interacts with GLD-3 via its conserved RNA-binding domain (Wu et al., 2013), it is possible that PUF-8 RNA-binding domain might interact with GLD-3 as well

IcoSema could be a true game-changer, as it would further reduce the number of injections to just 52 per year

Neuroreport 31 , 12831288 (2020)