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The price of the drug may have increased beyond what the insurance company is willing to pay

[DOI] [PubMed] [Google Scholar] 109.Wadden TA, Bailey TS, Billings LK, et al

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The effect intensifies during dose escalation, when patients move from lower to higher amounts of medication over several weeks

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In another study, we reported that linagliptin treatment increased glomerular and kidney tubular expression of SDF-1, as well as, circulating SDF-1 levels and ameliorated kidney injury in rat model of diabetic nephropathy [48]