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Obesity and weight management: How environmental factors contribute to energy imbalance

While these synthetic GLP-1 agonists have demonstrated remarkable efficacy in clinical trials, they are associated with a range of side effects, including common gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation, which are often dose-dependent (Kommu S et al., 2025

30,31 Furthermore, GLP-1RA has demonstrated the ability to reduce the activation of nuclear factor-kappa B (NF-B), a crucial inflammation controller, leading to a decrease in the generation of inflammatory agents

MYH9 and APOL1 gene polymorphisms and the risk of CKD in patients with lupus nephritis from an admixture population

A GLP-1-supportive snack prevents the spike-crash cycle

Patients should: Weigh themselves at the same time daily (particularly important for those with or at risk for heart failure), reporting sudden gains of 2-3 pounds overnight or 5 pounds within a week Note any new or worsening swelling in the legs, ankles, or abdomen Track blood pressure regularly, as hypertension often accompanies fluid retention Maintain a symptom diary including shortness of breath or reduced exercise tolerance Lifestyle modifications support healthy fluid balance