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The incorporation of real-world effectiveness and cost data into CEA complements the evidence derived from clinical trials and ensures that the results will be relevant for the real-life healthcare decision-making context [7, 8]

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They improve glucose control by increasing insulin release when blood sugar rises and by reducing inappropriate glucagon signaling

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29 We also used the CINeMA (Confidence in Network Meta-Analysis) framework to assess the certainty of the evidence in six key areas, including within-study bias, reporting bias, indirectness, imprecision, heterogeneity, and inconsistency