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It is important to note that Wegovy will remain available for eligible Medicare beneficiaries for other FDA-approved indications through their normal Part D benefits, including to reduce the risk of major adverse cardiovascular events in adults with established CV disease with either obesity or overweight

The increased pulse rate associated with tirzepatide was more pronounced in this cohort than in previous global studies, although its clinical significance remains uncertain

Inflammatory VAT, particularly perivascular and pericardial fat, exerts detrimental effects via the secretion of proinflammatory adipokines [51, 52]

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More long-term human studies are needed before drawing firm conclusions