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These effects are mediated primarily via activation of the vagal nerve, as pretreatment with atropine or bilateral cervical vagotomy abolishes ghrelin-induced gastric motility and acid secretion in rats [114, 115]

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While possible, you will likely gain the weight back if you don't partake in regular physical activities and exercise

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Gentle physical activity can also aid digestion

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The effect is small but contributes

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We did not pool mortality data in a meta-analysis because most deaths occurred in a single trial which recruited exclusively patients at increased cardiovascular risk (25 deaths with tirzepatide and 35 deaths with insulin glargine) [21]

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