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Semaglutide is the active ingredient in certain branded medications, including Wegovy and Ozempic

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This newly charted pathway - separate from previously described mechanisms that broadly affect appetite - could be an avenue by which GLP-1s treat other dysfunctions in reward processing, such as substance use disorder

Semaglutide was generally consistent with its known safety profile and showed some biomarker changes, but these did not translate into clinical benefit.