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Doctors uncover surprising causes, like artificial sweeteners and dehydration, and share easy fixes to calm the spasms.
Etiologies include syndromic disorders (Prader-Willi, Bardet-Biedl and Alstrm syndromes), monogenic defects of appetite-regulating pathways - most significantly melanocortin-4-receptor (MC4R) deficiency, but also leptin receptor (LEPR), pro-opiomelanocortin (POMC), and secondary hypothalamic injury, most commonly craniopharyngiomas
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Rapid weight loss with GLP-1 medications can deflate deep and superficial facial fat compartments, exposing laxity and altering contours.
