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GLP-1 therapies have become a key part of todays diabetes treatment algorithm, helping providers balance glucose control, cardiovascular risk, and patient preferences

Clinical evidence, encompassing trials, epidemiological investigations, and findings from animal toxicology and histological studies, has revealed potential associations between GLP-1RAs and the risk of neuroendocrine tumors and exocrine pancreatic dysplasia, with some evidence suggesting an increased risk of pancreatic cancer [6]

This approach ensures that donation remains safe for all parties involved whilst maximising the availability of this vital resource for patients who depend upon plasma-derived therapies

Glucagon has been known to increase heart rate for decades

Consistent with these data, while exendin-4 but not GLP-1 (936) has infarct limiting potential in the isolated rat heart, exendin-4 and GLP-1 (936) both improve left ventricular performance during reperfusion [626]

Study findings The study cohort consisted of 36,082 and 234,028 GLP-1 receptor agonist and DPP-4 inhibitor users, respectively, who were followed for a median of 1.3 and 1.7 years