glp 1 receptor agonists mechanism of action Possible mechanisms of glucagon-like peptide-1 on blood pressure beyond body weight glp 1 agonist mechanism of

10.1016/j.cell.2007.05.047 38 LiangW.KhatriI.SchellekensH.GarssenJ.WesterhoutJ

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Bloomberg (2023)

[67] studied a cohort of over 400,000 T2DM patients above the age of 65 and found that DPP-4i were associated with a 21% decrease in the risk of MACEs (including myocardial infarction and ischemic stroke) with a 46% overall decrease in risk of all-cause mortality

Additional trials are also underway in participants with type 1 diabetes targeting diverse pathways including oxidative stress, using nicotinamide adenine dinucleotide phosphate oxidase (Nox)-1/4 inhibitors, and the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, using bardoxolone (NCT03366337, NCT03550443) [84, 85]

The emergence of GLP-1RAs combined with glucose-dependent insulinotropic polypeptide and glucagon receptor agonists has shown promising results as new weight loss medications