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Abrupt discontinuation without a transition plan increases the likelihood of rapid weight regain and makes restarting therapy more difficult later

It is important to note that PIONEER 3 was a larger trial than PIONEER 12 (1864 participants vs 1441 participants, respectively) and had a longer duration (78 weeks with 5 weeks of follow-up vs 26 weeks with 5 weeks of follow-up, respectively) [18]

The link between obesity and heart health Obesity is strongly linked to heart health, with excess weight contributing to conditions like: high blood pressure high cholesterol type 2 diabetes blocked arteries (atherosclerosis) Research suggests that a BMI above 25 is strongly linked to a higher chance of cardiovascular death, particularly coronary heart disease or stroke

This keeps the patient coming back for check-ins and treatments, preventing them from seeking solutions elsewhere during the 612 months it takes to lose the weight