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In the STEP 3 trial of semaglutide combined with intensive lifestyle intervention (30 counseling visits across 68 weeks, including nutrition, physical activity, and other behavioral strategies, plus 8 initial weeks of meal replacements with liquid shakes, meal bars, or portion-controlled meals), individuals experienced a 16 % reduction from baseline in body weight (versus 5.7 % with intensive lifestyle intervention alone) [169]

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10.3945/ajcn.2009.28095 25 ChambersE