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Weight loss is a massive industry, with someone selling a new trick or surefire remedy for excess weight lurking around every corner

As the surrogate endpoint examples underline, achieving a surrogate endpoint does not always lead to clinical benefit

During the procedure, a small incision is made in the skin, and a cannula (thin tube) is inserted to suction out the fat

With small case numbers, statistics can change quickly, Rizzo noted

For example, genetic variants related to your FTO gene (linked to appetite regulation) or MC4R gene (involved in satiety signaling) can influence how aggressively your body responds to semaglutide and how your digestive tract handles the medication

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