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For patients considering a switch, PlexusDx also offers the Precision Peptide Genetic Test ($99 add-on after the first month of treatment), which analyzes key genetic variants in peptide-pathway genes like GLP1R and GIPR

Protein also has a higher thermic effect of food (20-30% of calories consumed) compared to carbohydrates (5-10%) or fats (0-3%), meaning the body expends more energy digesting and metabolizing protein

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These hypotheses remain speculative, as there is currently insufficient evidence to establish a direct causal relationship between tirzepatide and cold extremities
