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the level of CRP is related to the weight loss percentage treated with BN

This pathway has been beautifully illustrated by Krajnc et al

The mice were group-housed or single-housed on a 12:12 h light-dark cycle at 22-24C and were fed ad-libitum on a diabetogenic diet (6) which is a high-sucrose diet with 58% kcal from fat for 8 weeks before the initiation of the pharmacological studies

Consistent with this, GLP-1R agonism decreases a variety of reward behaviors in rodents, including the motivation to lever press for food reward in an operant conditioning test [746], alcohol intake [747,748], alcohol seeking behavior [747], amphetamine-induced conditioned place preference (Amp-CPP) [748], and hedonic feeding [748]

This aligns strongly with Ascend Medical's philosophy: medication plus lifestyle support equals meaningful, sustainable transformation

Similar neuroprotective effects have been reported in various PD rodent models treated with GLP-1R agonists [[844], [845], [846], [847], [848], [849]]