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[0010] In some particular embodiments of the present invention, the fully-protected fragment of Fmoc-PEG-PEG--Glu-octadecanedioic acid used in the fragmental synthesis of the Lys 26 side chain in the preparation method is prepared by successively coupling a chloride resin to Fmoc-PEG-OH, Fmoc-PEG-OH, Fmoc-Glu(OH)-OtBu and Octadecanedioic Acid mono-tert-butyl ester, cleaving, and recrystallizing to obtain PEG-PEG--Glu-Octadecanedioic Acid mono-tert-butyl ester

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2017;5(1):e000414

The results were remarkable, with participants losing an average of 15-17% of their initial body weight over 68-68 weeks

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