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PubMed Central , pmc.ncbi.nlm.nih.gov/articles/PMC6380979/.

The treatment protocol allows flexibility to prioritize tolerability while maintaining therapeutic benefit
Women using oral contraceptives should use an alternative or backup method for 4 weeks after tirzepatide initiation and with each dose increase due to potential reduced contraceptive effectiveness
When tirzepatide binds to GLP-1 receptors in the brain, particularly in the hypothalamus and brainstem, it sends powerful satiety signals

Tirzepatide is a once-weekly injectable medication initially developed to treat type 2 diabetes