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These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

Patients using oral birth control should consider adding a barrier method or switching to a non-oral contraceptive option (such as an IUD or implant) for at least four weeks after starting Zepbound and after each dose increase

This procedure is especially beneficial for patients who experience loose abdominal skin or muscle separation after significant weight loss

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Diabetes Care 41(2):356363 Karg MV, Bosch A, Kannenkeril D, Striepe K, Ott C, Schneider MP et al (2018) SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial