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First, needle avoidance a meaningful fraction of patients refused injectable therapy entirely

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But as far as I can tell, Amgen appears to have launched the product exclusively with Optum Rx

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GLP-1R action on brown adipose tissue (BAT) thermogenesis In addition to causing changes in feeding, central GLP-1R activation may regulate body weight by increasing brown adipose tissue (BAT) thermogenesis (reviewed in Lockie et al., 2013)