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doi: 10.1002/path.5056 177 HanWNHolscherCYuanLYangWWangXHWuMNet al

These factors include starting weight, adherence to dietary and exercise guidelines, and metabolic factors

It assists in monitoring the condition and determining what tests or therapy are required

Dehydration is a well-established cause of headache and may occur with GLP-1 medications due to reduced fluid intake (from appetite suppression) or increased fluid loss (from gastrointestinal side effects such as nausea, vomiting, or diarrhoea)

Further reading on observed adverse signal profiles from the investigational phase 2 programme is available in the Retatrutide Side Effects: Detailed Guide with Clinical Trial Insights 2026 article, which summarises published tolerability data for research planning purposes

These are all important factors to consider when talking to your healthcare provider about using these medications to lose weight