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However, research in this area continues with several companies exploring novel GLP-1 treatment strategies

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[19] [20] The risk of hypoglycemia increases when these medications are combined with insulin or sulfonylureas, often requiring dose adjustments of these agents

The most common side effects reported in trials include: Digestive issues Nausea (the most frequently reported side effect) Vomiting Diarrhoea Constipation Stomach pain or discomfort Loss of appetite Other reported effects Fatigue or tiredness Injection site reactions (redness, swelling, or irritation) Most side effects tend to be worse when starting the medication or increasing the dose, and often improve as your body adjusts