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In this setting, GLP-1 RAs were administered at lower doses indicated for glycemic control rather than weight management

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Development of GLP-1 receptor agonists The most important strategy to develop compounds with extended in vivo half-life of GLP-1 was by making DPP-4 resistant GLP-1 receptor agonists

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Life Sci 126:8186

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Gallwitz B, Giorgino F

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