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Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance

Insr floxed mice (IR F/F

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By contrast, Trulicitys AWARD-11 trial showed the highest dose (4.5 mg) produced a weight reduction of approximately 4.7 kg (~10.4 lbs) at 36 weeks-a modest but clinically meaningful secondary benefit for patients primarily managing type 2 diabetes