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2020;5, article 140532 doi: 10.1172/jci.insight.140532
Human trials are ongoing, but even modest effects in opioid use disorder could be clinically meaningful given the favorable safety profile of GLP-1 drugs compared with existing treatments

Interestingly, these effects were generated in the fasting state (i.e., when glucose levels, and hence GLP-1 levels, should have been lowest) and in isolated islets to observe impact on both the basal and stimulated insulin secretion

Youll also want to exercise caution if you are taking any oral medications

Rodbard H, Lingvay I, Reed J, et al

A 5-day delayed dose should cause minimum semaglutide concentrations to be 37% lower and maximum concentrations to be 14% higher compared with the same subject at normal weekly steady state (Fig
