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Return to Article Details GLP-1 receptor agonists in type 2 diabetes - NICE guidelines versus clinical practice

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Chinas growing diabetic patient base and increased government initiatives for diabetes care contribute to market growth

Plasma levels of pro- and anti-inflammatory cytokines were increased in wild-type (WT) but not in TLR4-deficient (Tlr4/) mice, while GLP-1 secretion could be abolished when STC-1 cells were exposed to LPS in the presence of a TLR4 antagonist (TAK-242)

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Safety and tolerability issues were also similar across groups, suggesting that dose adjustment is not required in patients with hepatic impairment