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Some of the remaining undigested organic bone matrix is subsequently degraded by collagenases (especially histone K) (Lu et al., 2018)

Gudin B, Ladhari C, Robin P, Laroche ML, Babai S, Hillaire-Buys D, Faillie JL

Accumulation of cytosolic dsDNA contributes to fibroblast-like synoviocytes-mediated rheumatoid arthritis synovial inflammation

Baillieres Clin Gastroenterol 1997;11:485-507 View Abstract [7] Corazza GR, Gasbarrini G

A key differentiating feature is the attachment of a C18 fatty acid via a spacer to Lys at the 26th position, facilitating strong binding to albumin and thereby significantly prolonging plasma half-life

A randomized, double-blind, placebo-controlled study performed by Watson et al