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While numerous proof-of-concept candidate molecules have been disclosed ( and Zepbound ) ( ex vivo finding, the GIPR monoagonist LY3537021 reduced body weight by ~4.1% over 8 weeks in patients with T2D (n = 18) ( 2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) ( It has been hypothesized that the deleterious, nauseating effects of GLP-1R agonists and the beneficial, food-intake reducing effects are inextricably linked

Obesity often helps cause other health problems

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Open 4 , e213520 (2021)

Researchers concluded that those taking tirzepatide were significantly more likely to achieve weight loss, but added that more studies are needed to better understand the full range of benefits and effects both drugs have on patients

Other potential side effects to be aware of include injection site reactions (redness, itching, or swelling), headache, fatigue, and dizziness