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In the head-to-head SURMOUNT-5 trial, tirzepatide achieved 20.2% mean weight reduction compared to 13.7% with semaglutide at 72 weeksa difference of 6.5 percentage points

Setting phone reminders to drink water every 2-3 hours helps maintain hydration when natural thirst signals are unreliable

GLP-1 has always been around and has always been part of a well-functioning body and brain

It could be hormonal, behavioral, or related to social factorsor some combination of all three. Can you lose too much weight on a GLP-1

Roche's public obesity strategy, as of April 2026, centers on CT-388 (a GLP-1/GIP dual acquired through the Carmot Therapeutics acquisition) and a deep orforglipron-competitor oral GLP-1 program

In a letter to the National Association of Boards of Pharmacy, the FDA warned that the agency has not evaluated semaglutide acetate or semaglutide sodiumtwo types of semaglutide saltsfor safety or efficacy
