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Clinical considerations : Transdermal delivery is often preferred to reduce thrombotic risk

It enrolls approximately 10,000 participants with established cardiovascular disease, uses MACE as the primary endpoint, and is on a 3-4 year timeline

We discuss potential risks and benefits thoroughly during your consultation

For patients with type 2 diabetes, dosage adjustments of concomitant oral and antidiabetic products may be needed

The improvement in HbA 1c following GLP-1 RA may primarily be driven by weight loss [50], but the mechanism may be more nuanced in individuals with type 1 diabetes and normal body weight

[14] In patients with diabetes, overly aggressive glycemic control or inadequate adjustment of concurrent diabetes medications (particularly insulin or sulfonylureas) may result in hypoglycemia or relative hypoglycemia, even if glucose values remain within normal range