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50 Contrary to preclinical literature about the positive role of GLP-1 RAs on the rewarding and reinforcing behavior of drug abuse, the study in our review proposed that exenatide treatment did not help with euphoria and cocaine craving in the subjects

In Phase 3 SURMOUNT trials, Retatrutide achieved unprecedented 24.2% mean weight loss at the 12mg dose over 48 weeks, with 91% of participants achieving 15% body weight reduction

One long-term study in 2024 found people who exercised while using a weight-loss drug kept off far more pounds after quitting the medication than people who didnt work out

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Can compounded tirzepatide be as safe as Mounjaro

Not all patients respond equally to GLP-1 agonist therapy, and identifying optimal candidates requires considering multiple factors, including baseline weight, comorbidities, and individual tolerance profiles