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semaglutide mouse ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis Distinct metabolic effects of semaglutide
Description
In STEP 1, the largest clinical trial, semaglutide takers lost, on average, 15 percent of their initial weight, or about 35 pounds, after 68 weeks

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However, both groups experienced the same rate of serious adverse events (13%)

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In light of the unclear hemodynamic picture, a RHC is done, showing a RA pressure 9, RV pressure of 80/10, PAP 70/25 with mPAP 40, PCWP 30, SVR 872, CO 11 (by thermodilution), and CI 5.2
