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Study procedure (Koide et al., 2025) GLP-1RA therapy significantly reduced blood glucose levels, body weight, and body fat percentage Results showed that after 12 months of treatment, GLP-1RA therapy significantly reduced participants blood glucose levels (as measured by glycated hemoglobin), body weight, and body fat percentage

Compared to the lead structure 7, nearly all produced compounds were found to be good selective inhibitors for DPP-4

doi: 10.1016/S2213-8587(16)30328-X
And not all studies found the same link, so the evidence is mixed

The most realistic benefit of TRT is not rapid weight loss, like many other weight loss pharmaceuticals on the market, Honomichl said
Reduced fat mass may support healthier testosterone levels, helping with energy, mood, and motivation
