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Sitagliptin was approved in 2006, but in contrast to the GLP-1 agonists, DPP4 inhibitors have little or no effect on body weight

Without resistance training, your body treats muscle tissue as expendable during a caloric deficit, breaking it down for amino acids and energy while preserving fat stores, because from an evolutionary perspective, fat is more calorically dense and therefore more valuable during a famine

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Figure S9

Additionally, lifestyle factors such as diet and exercise play a vital role in determining the success of weight loss treatment