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Description
They minimize systemic inflammation by many mechanisms: direct suppression of pro-inflammatory cytokine synthesis (TNF-, IL-6, IL-1), augmentation of anti-inflammatory mediators (IL-10, adiponectin), and alteration of immune cell morphologies

In humans, DPP-4is, including sitagliptin, have demonstrated a significant ability to decrease systemic inflammatory mediators such as CRP and IL-6 in patients with T2DM [82]
10.1016/j.molmet.2020.101102

Maintaining weight loss after tirzepatide requires deliberate strategies: established exercise habits, protein-prioritized nutrition, and in some cases, transitioning to a lower maintenance dose rather than stopping completely

American Society of Echocardiography

Drink 8-12 ounces immediately upon waking
