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Funnel plots showed a symmetrical distribution of most SNPs around the central estimate, indicating the absence of significant directional pleiotropy or bias (Supplementary Figure S3)

Cesare Patrone, Karolinska Institutet (KI), Sweden Updates Copyright 2020 Kim, Kim and Song

doi: 10.7150/ijbs.59965 119 HamalSCherukuriLShaikhKKinningerADoshiJBirudarajuDet al

There are five known subtypes of Y receptors, namely, Y1R, Y2R, Y4R, Y5R, and Y6R
Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes and obesity, have evolved into multi-organ potential therapeutics due to their pleiotropic effects beyond glycemic control

The percentage of participants who had weight reduction of 5% or more was 85%, 89%, and 91% with 5 mg, 10 mg, and 15 mg of tirzepatide, respectively, and 35% with placebo
