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Reducing the risk of withdrawal symptoms and relapse following clozapine discontinuation-is it feasible to develop evidence-based guidelines

But it does require precision

Sympathetic activation was evident, with higher plasma norepinephrine levels and increased FosB expressiona marker of sustained neuronal excitationin the parvocellular paraventricular nucleus and the rostral ventrolateral medulla

This is not true pharmacological tolerance in the classic sense, but rather the body finding a new equilibrium at the current level of receptor stimulation

Introduction Diabetes and obesity are chronic diseases leading to substantial morbidity and high mortality worldwide, especially in developed countries

The goal is not to shame or judge