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GIP activation may additionally potentiate the insulin secretion effects of GLP-1 activation on the pancreas and the weight loss effects of GLP-1 activation on CNS [13]

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46 Several preclinical and clinical studies on ischemia-induced brain injury, Alzheimers disease (AD), Parkinsons disease (PD), and other neurodegenerative disorders have established that GLP-1RAs can cross the BBB and exert a significant neuroprotective effect