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The effects of cAMP-increasing agents on force of contraction can often be augmented by a phosphodiesterase inhibitor

Growth hormone treatment and risk of malignancy

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doi: 10.1002/(ISSN)1096-9861 183 RossCARuggieroDAJohTHParkDHReisDJ

In this case, the affinity would weaken if Glu was replaced with a lactam bridge because the charge would be dispersed