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The concept of permanent metabolic damage has been largely debunked by controlled research, though it remains a persistent myth in weight loss communities

They mimic gut hormones that play a role in digestion and metabolism, prompting weight loss and acting on the body in a smorgasbord of other ways, some still unknown

Regulatory approvals have focused on weight loss efficacy as the primary endpoint with cardiovascular benefits considered secondary outcomes

1, Extended Data Tables 16 and Supplementary Section 2), with a clear trend of growing relevant literature over the past few years as the use of these medications becomes more widespread and their indications expand far beyond the initial intentions of the manufacturers 223

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We used HepG2 cells treated with Oleic Acid (OA) as a model of hepatic steatosis in this study to see if direct activation of the GLP-1R with Ex-4 affects any of the four processes listed above and thus improves steatosis